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cgp55845 hydrochloride  (Tocris)
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(a) Left, average M1 synaptic response in a L2 pyramidal cell of S1 evoked by a single optical stimulus in control conditions (black) and after adding baclofen (2.5 µM, magenta), with and without CGP-55845 (4 µM) in the bath. Right, population data showing the average time course of baclofen effects (30 sec application) on M1 evoked EPSC amplitudes with or without <t>CGP55845</t> in the bath (n = 4 cells, 3 mice). (b) Dose-response relationship of baclofen suppression on M1 (black) EPSC amplitudes: 0.31 µM (n = 5 cells, 2 mice), 0.63 µM (n = 5 cells, 2 mice), 1.25 µM (n = 4 cells, 2 mice), 2.5 µM (n = 13 cells, 9 mice), 5 µM (n = 7 cells, 4 mice), 10 µM (n = 4 cells, 4 mice), 20 µM (n = 6 cells, 4 mice). The effect of baclofen on POm (red) synaptic responses is also plotted for 2.5 µM (n = 8 cells, 3 mice) and 10 µM (n = 4 cells, 2 mice).
Cgp55845 Hydrochloride, supplied by Tocris, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cgp55845 hydrochloride/product/Tocris
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cgp55845 hydrochloride - by Bioz Stars, 2026-04
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cgp55845  (Tocris)
95
Tocris cgp55845
(a) Left, average M1 synaptic response in a L2 pyramidal cell of S1 evoked by a single optical stimulus in control conditions (black) and after adding baclofen (2.5 µM, magenta), with and without CGP-55845 (4 µM) in the bath. Right, population data showing the average time course of baclofen effects (30 sec application) on M1 evoked EPSC amplitudes with or without <t>CGP55845</t> in the bath (n = 4 cells, 3 mice). (b) Dose-response relationship of baclofen suppression on M1 (black) EPSC amplitudes: 0.31 µM (n = 5 cells, 2 mice), 0.63 µM (n = 5 cells, 2 mice), 1.25 µM (n = 4 cells, 2 mice), 2.5 µM (n = 13 cells, 9 mice), 5 µM (n = 7 cells, 4 mice), 10 µM (n = 4 cells, 4 mice), 20 µM (n = 6 cells, 4 mice). The effect of baclofen on POm (red) synaptic responses is also plotted for 2.5 µM (n = 8 cells, 3 mice) and 10 µM (n = 4 cells, 2 mice).
Cgp55845, supplied by Tocris, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cgp55845/product/Tocris
Average 95 stars, based on 1 article reviews
cgp55845 - by Bioz Stars, 2026-04
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hy-103516  (medchemexpress)
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(a) Left, average M1 synaptic response in a L2 pyramidal cell of S1 evoked by a single optical stimulus in control conditions (black) and after adding baclofen (2.5 µM, magenta), with and without CGP-55845 (4 µM) in the bath. Right, population data showing the average time course of baclofen effects (30 sec application) on M1 evoked EPSC amplitudes with or without <t>CGP55845</t> in the bath (n = 4 cells, 3 mice). (b) Dose-response relationship of baclofen suppression on M1 (black) EPSC amplitudes: 0.31 µM (n = 5 cells, 2 mice), 0.63 µM (n = 5 cells, 2 mice), 1.25 µM (n = 4 cells, 2 mice), 2.5 µM (n = 13 cells, 9 mice), 5 µM (n = 7 cells, 4 mice), 10 µM (n = 4 cells, 4 mice), 20 µM (n = 6 cells, 4 mice). The effect of baclofen on POm (red) synaptic responses is also plotted for 2.5 µM (n = 8 cells, 3 mice) and 10 µM (n = 4 cells, 2 mice).
Hy 103516, supplied by medchemexpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
hy-103516 - by Bioz Stars, 2026-04
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(a) Left, average M1 synaptic response in a L2 pyramidal cell of S1 evoked by a single optical stimulus in control conditions (black) and after adding baclofen (2.5 µM, magenta), with and without CGP-55845 (4 µM) in the bath. Right, population data showing the average time course of baclofen effects (30 sec application) on M1 evoked EPSC amplitudes with or without CGP55845 in the bath (n = 4 cells, 3 mice). (b) Dose-response relationship of baclofen suppression on M1 (black) EPSC amplitudes: 0.31 µM (n = 5 cells, 2 mice), 0.63 µM (n = 5 cells, 2 mice), 1.25 µM (n = 4 cells, 2 mice), 2.5 µM (n = 13 cells, 9 mice), 5 µM (n = 7 cells, 4 mice), 10 µM (n = 4 cells, 4 mice), 20 µM (n = 6 cells, 4 mice). The effect of baclofen on POm (red) synaptic responses is also plotted for 2.5 µM (n = 8 cells, 3 mice) and 10 µM (n = 4 cells, 2 mice).

Journal: bioRxiv

Article Title: Presynaptic control of top-down signaling in neocortical layer 1

doi: 10.64898/2026.01.31.703032

Figure Lengend Snippet: (a) Left, average M1 synaptic response in a L2 pyramidal cell of S1 evoked by a single optical stimulus in control conditions (black) and after adding baclofen (2.5 µM, magenta), with and without CGP-55845 (4 µM) in the bath. Right, population data showing the average time course of baclofen effects (30 sec application) on M1 evoked EPSC amplitudes with or without CGP55845 in the bath (n = 4 cells, 3 mice). (b) Dose-response relationship of baclofen suppression on M1 (black) EPSC amplitudes: 0.31 µM (n = 5 cells, 2 mice), 0.63 µM (n = 5 cells, 2 mice), 1.25 µM (n = 4 cells, 2 mice), 2.5 µM (n = 13 cells, 9 mice), 5 µM (n = 7 cells, 4 mice), 10 µM (n = 4 cells, 4 mice), 20 µM (n = 6 cells, 4 mice). The effect of baclofen on POm (red) synaptic responses is also plotted for 2.5 µM (n = 8 cells, 3 mice) and 10 µM (n = 4 cells, 2 mice).

Article Snippet: Pharmacological agents included R-Baclofen (Tocris, Cat# 0796), CGP55845 hydrochloride (Tocris, Cat# 1248), and Picrotoxin (Sigma, Cat# P1675).

Techniques: Control